Production of modified pe40

Details Production of modified pe40 Production of modified pe40

C - Chemistry, Metallurgy

12

N

530/13

C12N 9/10 (2006.01) A61K 47/48 (2006.01) C07K 14/21 (2006.01) C07K 14/485 (2006.01) C07K 14/495 (2006.01)

Patent

CA 2012732

The present invention provides modifications of the PE40 domain which eliminate the chemical ambiguities caused by the cysteines in PE40. Substitution of other amino acids such as, e.g., alanine for the cysteine residues in PE40, or deletion of two or more of the cysteine residues improves the biological and chemical properties of conjugates formed between modified PE40 and a targeting agent.

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