Production of monatin enantiomers

C - Chemistry – Metallurgy – 12 – P

Patent

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Details

C12P 17/10 (2006.01) C12Q 1/34 (2006.01) C07D 209/20 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2701153

Methods for preferentially hydrolyzing one stereoisomer of an isoxazoline diester over another, as well as an enzyme for facilitating the preferential hydrolysis are provided. Also provided are methods for providing mixtures of (RR) and (RS) monatin as well as (SS) and (SR) monatin, which methods can include the step of stereoselectively hydrolyzing an isoxazoline diester.

L'invention porte sur des procédés pour hydrolyser un stéréoisomère d'un diester d'isoxazoline préférentiellement à un autre, ainsi que sur une enzyme pour faciliter l'hydrolyse préférentielle. L'invention propose également des procédés pour fournir des mélanges de (RR) et (SS) monatines ainsi que de (SS) et (SR) monatines, lesquels procédés peuvent comprendre l'étape d'hydrolyse stéréosélective d'un diester d'isoxazoline.

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