C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/00 (2006.01) C07D 473/24 (2006.01) C07H 19/16 (2006.01)
Patent
CA 2140408
A process for the preparation of a purine derivative corresponding to the following general formula: Image characterised in that it comprises: protecting the hydroxyl groups of the sugar moiety of a starting material corresponding to the following general formula: Image activating the 6-position of the purine ring; introducing the substituent B at this position; and removing the sugar moiety; wherein A represents NH2 or H; B represents a substituent which has the effect of favouring subsequent substitution at the 9-position of the purine ring and which will withstand removal of the sugar moiety, but which may later be removed or converted; and 29 Z represents: Image is disclosed. The present purine derivatives obtainable by the above process may be used in a disclosed process for the preparation of a nucleoside analogue characterised in that it comprises: introducing a side chain at the 9-position of the purine derivative; and removing or converting the substituent B at the 6-position of the purine derivative.
Reese Colin
Sim & Mcburney
LandOfFree
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