C - Chemistry – Metallurgy – 12 – M
Patent
C - Chemistry, Metallurgy
12
M
C12M 1/00 (2006.01) C07K 14/615 (2006.01) C12N 1/00 (2006.01) C12P 21/00 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2392268
The invention relates to a method for the production of recombinant peptides by fedbatch cultivation of a microorganism in a bioreactor containing a medium comprising organic carbon source, nitrogen source and mineral salts. The cultivation is carried out by the addition of the organic carbon source by oscillation feed and/or by oscillation variation of stirring speed, e.g. in a square or sinus wave pattern. Preferably the organic carbon source is glucose and the recombinant peptide is growth hormone.
L'invention concerne un procédé de production de peptides recombinants par culture discontinue d'un micro-organisme dans un bioréacteur contenant un milieu composé d'une source de carbone organique, d'une source d'azote, et de sels minéraux. La culture est effectuée par addition de la source de carbone organique par alimentation oscillatoire et/ou par variation oscillatoire de la vitesse de mélange, par ex. selon une onde de type carrée ou sinusoïdale. De préférence, la source de carbone organique est du glucose et le peptide recombinant est une hormone de croissance.
Ab Pharmacia
Gowling Lafleur Henderson Llp
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