Production of peptides in plants as viral coat protein fusions

Details Production of peptides in plants as viral coat protein fusions Production of peptides in plants as viral coat protein fusions

C - Chemistry, Metallurgy

12

N

C12N 15/83 (2006.01) C07K 14/08 (2006.01) C07K 14/445 (2006.01) C07K 19/00 (2006.01) C12N 7/01 (2006.01) C12N 15/40 (2006.01) C12N 15/62 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2202652

The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthezised in plants at high levels by biologically contained tobamoviruses. The fusion proteins of the invention have many uses. Such uses include use as antigens for inducing the production of antibodies having desired binding properties, e.g., protective antibodies, or for use as vaccine antigens for the induction of protective immunity, including immunity against parasitic infections.

L'invention concerne des séquences de peptides étrangers fusionnées avec des protéines végétales de recombinaison, structurales et virales et leur procédé de production. On synthétise de manière économique et à des taux élevés des protéines de fusion dans des végétaux à l'aide de tomabovirus contrôlés biologiquement. Les protéines de fusion selon l'invention peuvent avoir plusieurs utilisations. Ces utilisations comprennent l'utilisation en tant qu'antigènes pour induire la production d'anticorps présentant les propriétés de liaison désirées, telles que des anticorps protecteurs ou en tant qu'antigènes vaccins pour l'induction de l'immunité protectrice dont l'immunité contre les infections parasitaires.

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