Production of products of pharmaceutical interest in plant...

Details Production of products of pharmaceutical interest in plant... Production of products of pharmaceutical interest in plant...

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A01H 5/00 (2006.01) A61K 38/00 (2006.01) C12N 5/04 (2006.01) C12N 15/09 (2006.01) C12N 15/82 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2738571

The present invention relates to transgenic plant cell cultures comprising transgenic plant cells comprising a plurality of nucleic acids heterologous to said plant, each of said nucleic acids comprising a coding sequence encoding a pharmaceutical product of interest operably linked to one or more regulatory elements for directing expression of said coding sequence in said plant cell, said nucleic acids being stably integrated at or adjacent to native rDNA of said plant cell; methods of producing the transgenic plant cell culture; and methods of producing a pharmaceutical product of interest using the transgenic plant cell culture.

Cette invention concerne des cultures de cellules de plantes transgéniques comprenant des cellules de plantes transgéniques contenant une pluralité d'acides nucléiques hétérologues à ladite plante, chacun desdits acides nucléiques comprenant une séquence codante, codant pour un produit pharmaceutique d'intérêt, liée de manière opérationnelle à un ou plusieurs éléments de régulation destinés à diriger l'expression de ladite séquence codante dans ladite cellule végétale, lesdits acides nucléiques étant intégrés de manière stable dans la séquence de l'ADNr natif de ladite cellule végétale, ou en une position adjacente. Linvention concerne également des procédés de production de la culture de cellules de plantes transgéniques et des procédés de production d'un produit pharmaceutique d'intérêt au moyen de ladite culture de cellules de plantes transgéniques.

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