C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 39/12 (2006.01) A61K 48/00 (2006.01) C12N 15/861 (2006.01) C12N 15/864 (2006.01)
Patent
CA 2385823
This invention relates to novel adenoviruses useful in the production of high titers of recombinant adeno-associated virus (rAAV) comprising a foreign DNA insert and methods of making these adenoviruses. The adenovirus comprises the AAV rep gene in which the p5 promoter of rep is replaced by a minimal promoter or by no promoter. The invention also provides methods of producing high levels of rAAV as a substantially homogeneous preparation and compositions of rAAV.
La présente invention concerne de nouveaux adénovirus utiles dans la production de titres élevés de virus associés à l'adénovirus recombinants (AAVr) comprenant un insert d'ADN étranger et des procédés de fabrication desdits adénovirus. Les adénovirus comportent le gène AAV rep dans lequel le promoteur p5 de rep est substitué par un promoteur minimal ou par aucun promoteur. L'invention concerne également des procédés de production de AAVr de haut niveau sous forme d'une préparation sensiblement homogène et des compositions de AAVr.
Chen Haifeng
Kurtzman Gary
Borden Ladner Gervais Llp
Genovo Incorporated
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