Production of recombinant polypeptides by bovine species and...

C - Chemistry – Metallurgy – 12 – N

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C12N 15/85 (2006.01) A01K 67/027 (2006.01) A23C 9/00 (2006.01) A23C 9/20 (2006.01) C07K 14/47 (2006.01) C07K 14/765 (2006.01) C07K 14/79 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2075206

A transgene for producing recombinant polypeptides in the milk of transgenic bovine species comprises at least one expression regulation sequence, a secretory DNA sequence encoding a secretory signal which is functional in mammary secretory cells of the bovine species and a recombinant DNA sequence encoding the recombinant polypeptides. A method for producing transgenic bovine species comprises introducing the above transgene into an embryonal target cell of a bovine species, transplanting the transgenic embryonic target cell formed thereby into a recipient bovine parent and identifying at least one female offspring which is capable of producing the recombinant polypeptide in its milk. The invention also includes transgenic bovine species capable of producing recombinant polypeptides in transgenic milk as well as the milk from such transgenic bovine species and food formulations containing one or more recombinant polypeptide. A method for producing transgenic non-human mammals having. a desirable phenotype comprises first methylating a transgene followed by introduction into fertilised oocytes. The oocytes are then cultured to form preimplantation embryos. Thereafter, at least one cell is removed from each of the pre-implantation embryos and the DNA digested with a restriction endonuclease capable of cleaving the methylated transgene but incapable of cleaving the unmethylated form of the transgene.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Production of recombinant polypeptides by bovine species and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Production of recombinant polypeptides by bovine species and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Production of recombinant polypeptides by bovine species and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1418095

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.