Production of solid solutions based on poorly-soluble active...

A - Human Necessities – 61 – K

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A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/26 (2006.01) A61K 9/48 (2006.01) A61K 31/07 (2006.01) A61K 31/405 (2006.01) A61K 31/4174 (2006.01) A61K 31/426 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/5415 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2611083

The invention relates to a method for producing powdered or granulated solid solutions from poorly-soluble substances which are molecularly dispersed in an auxiliary agent matrix consisting in atomising a solution containing the poorly-soluble active substance and matrix auxiliary agents, in heating the aqueous suspension of the poorly-soluble substance in the presence of the matrix auxiliary agents to temperatures which are higher than the boiling temperature thereof at a normal pressure, in transforming the poorly-soluble active substance into a solution, in solidifying the solution containing said poorly-soluble substance and matrix auxiliary agents by atomising and drying, wherein the spray solution has a temperature ranging from 90 ~C to 350 ~C prior to be introduced into an atomising device.

L'invention concerne un procédé pour produire des solutions solides se présentant sous la forme de poudres ou de granulés, à partir de substances peu solubles, la substance peu soluble étant dispersée moléculairement dans une matrice constituée d'adjuvants. Le procédé selon l'invention consiste à atomiser une solution comprenant la substance active peu soluble et les adjuvants matriciels ; à chauffer une suspension aqueuse de la substance peu soluble, en présence des adjuvants matriciels, pour qu'elle atteigne des températures supérieures à la température d'ébullition, à une pression normale, et à transformer la substance peu soluble en solution, puis ; à solidifier la solution comprenant la substance peu soluble et les adjuvants matriciels, par atomisation et séchage, la solution pulvérisée présentant une température comprise entre 90 °C et 350 °C avant d'être introduite dans le dispositif d'atomisation.

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