C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A01K 67/027 (2006.01) C07K 14/48 (2006.01) C12N 9/00 (2006.01) C12N 15/85 (2006.01) C12N 15/869 (2006.01)
Patent
CA 2237392
The present invention relates to recombinatorial substrates which include a promoter, a terminator, a gene positioned 3' to the terminator and whose expression is to be controlled, and recombination sites on each side of the terminator such that when the substrate is treated with a specific recombinase the gene will be expressed. Recombinatorial substrates which have a promoter, a gene to be controlled, and recombination sites on each side of the gene which when treated with recombinase delete the gene are also provided. Also enclosed are methods of creating transgenic mammals carrying the recombinatorial substrate and methods for activating the recombinatorial substrate.
L'invention concerne des substrats recombinatoires comprenant un promoteur, un terminateur, un gène positionné en 3' par rapport au terminateur et dont l'expression est à diriger, et des sites de recombinaison de chaque côté du terminateur de sorte que lorsque le substrat est traité avec une recombinase spécifique, le gène soit exprimé. L'invention concerne également des substrats recombinatoires présentant un promoteur, un gène à diriger et des sites de recombinaison de chaque côté du gène qui, une fois traité avec la recombinase, provoque la délétion du gène. L'invention concerne en outre des procédés de création de mammifères transgéniques portant le substrat recombinatoire et des procédés d'activation du substrat recombinatoire.
Gowling Lafleur Henderson Llp
University Of Rochester
LandOfFree
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