Production of thorium 228 starting from a natural thorium salt

C - Chemistry – Metallurgy – 01 – F

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C01F 15/00 (2006.01) A61K 51/10 (2006.01)

Patent

CA 2681180

The invention relates to a process for producing 228Th from a natural thorium salt, which comprises in succession: a) the separation of the radium from the other radioelements present in this salt, by at least one coprecipitation of the radium by barium sulphate, this coprecipitation comprising: i) the addition of sulphuric acid and a barium salt to an aqueous solution of said natural thorium salt in order to form a barium-radium sulphate coprecipitate and ii) the separation of the coprecipitate from the medium in which it has formed; b) the extraction of the thorium 228 coming from the decay of radium 228 from the coprecipitate thus separated; and, optionally c) the purification and concentration of the 228Th thus extracted. Applications: manufacture of radiopharmaceutical products useful in nuclear medicine, in particular in radioimmunotherapy for the treatment of cancers and AIDS.

La présente invention concerne un procédé de production de 228Th à partir d'un sel de thorium naturel, qui comprend, successivement : a) la séparation du radium des autres éléments radioactifs présents dans ce sel, par au moins une coprécipitation du radium par le sulfate de baryum, cette coprécipitation comprenant : i) l'addition d'acide sulfurique et d'un sel de baryum à une solution aqueuse dudit sel de thorium naturel de manière à former un coprécipité baryum-sulfate de radium et ii) la séparation du coprécipité du milieu dans lequel il s'est formé ; b) l'extraction du thorium 228 provenant du déclin du radium 228 du coprécipité ainsi séparé ; et, facultativement c) la purification et la concentration du 228Th ainsi extrait. Applications : fabrication de produits pharmaceutiques radioactifs utiles en médecine nucléaire, en particulier en radioimmunothérapie pour le traitement de cancers et du SIDA.

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