Production of ultrapure bismuth-213 for use in therapeutic...

C - Chemistry – Metallurgy – 01 – G

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C01G 29/00 (2006.01) B01J 39/04 (2006.01) G01N 30/88 (2006.01) G21G 4/08 (2006.01) B01D 15/26 (2006.01) B01D 15/36 (2006.01) G01N 30/08 (2006.01) G01N 30/46 (2006.01)

Patent

CA 2451676

A multicolumn selectivity inversion generator has been developed in which bismuth-213 is selectively extracted from an HC1 solution of the actinium-225 parent (and its radiogenic descendents) by a primary separation column containing a separation medium containing a neutral oxygenated organophosphorus extractant. After rinsing with dilute HC1, the bismuth-213 is stripped with a buffered NaC1 solution. The stripped solution is passed through a cation-exchange resin guard column that retains the actinium-225 and radium-225 contaminants while the bismuth-213 elutes. This generator method minimizes the unpredictable effects of radiation damage to the support material and permits the reliable production of bismuth-213 of high chemical and radionuclidic purity.

L'invention concerne un générateur multicolonnes à inversion de sélectivité dans lequel le bismuth-213 est extrait sélectivement d'une solution de HCl contenant l'actinium-225 parent (et ses descendants radiogéniques) par une colonne de séparation primaire qui renferme un milieu de séparation contenant un agent d'extraction organophosphoré oxygéné neutre. Après son rinçage avec le HCl dilué, le bismuth-213 est ôté avec une solution de NaCl tamponnée. La solution dépouillée est passée à travers une colonne de garde à résine échangeuse de cations, qui retient les impuretés d'actinium-225 et de radium-225 pendant l'élution du bismuth-213. Ce procédé de génération réduit au minimum les effets imprévisibles des détériorations par rayonnements infligés au matériau de support, et permet la production fiable d'un bismuth-213 d'une grande pureté chimique et radioactive.

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