C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2199212
A method is described to transfer a gene encoding a valuable compound, such as a pharmaceutical, into the secretory cells of the mammary gland to produce a new compound into the milk or to alter the composition of the milk. In this method the packaging cell line producing the viral-derived particles is infused into the mammary gland. The packaging cells will attach and survive for a period of time within the mammary gland. While the cells are viable, they will supply a continuous source of viral- derived particles to trans-infect the maximum number of mammary epithelial cells. After a period of time in the mammary gland, both the particles and the packaging cells will be destroyed by natural mechanisms while the trans- infected mammary epithelial cells continue to express gene(s) encoding the valuable compound or gene(s) to alter the composition of the milk. One or more genes can be trans-infected including DNA sequences that contribute to the efficient production of an active compound or to its stability. The packaging cells and the viral-derived particles used in this method can be those which trans-infect dividing or non-dividing cells and can be used either singly or together. This method can be used alone or in combination with other novel methods designed to ensure that the viral-derived particles are correctly positioned to trans-infect the mammary epithelial cells. Increasing the trans-infection of the mammary epithelial cells with the viral particles will result in a higher concentration of the valuable compound in the milk.
Benkel Bernhard
Falconer Marcia M.
Gavora Jan S.
Nguyen Thuy H.
Gowling Lafleur Henderson Llp
Her Majesty The Queen In Right Of Canada As Represented By Minister Of Agriculture And Agri-Food
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