Production process for polymeric micelle charged therein...

Details Production process for polymeric micelle charged therein... Production process for polymeric micelle charged therein...

A - Human Necessities

61

K

A61K 47/42 (2006.01) A61K 9/51 (2006.01) A61K 31/337 (2006.01) A61K 31/4745 (2006.01) A61K 47/30 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) A61P 35/00 (2006.01) A61K 9/107 (2006.01)

Patent

CA 2334615

Provided are a production process for a polymeric micelle which is stable and has a high drug content and a composition con- taining such polymeric micelle. Disclosed are a production process for a polymeric micelle, comprising the steps of dissolving a drug and a specific copolymer in a water non-miscible organic solvent to pre- pare a solution, mixing the resulting solution with water to form an O/W type emulsion and then slowly volatilizing the organic solvent from the solution, and a polymeric micelle composition charged therein with a water-scarcely soluble drug, which can be obtained by the above production process.

On propose un procédé de fabrication d'une micelle polymérique stable à teneur élevée en médicament et d'une composition renfermant une telle micelle. On divulgue un procédé de fabrication d'une micelle polymérique comprenant les étapes de dissolution d'un médicament et d'un copolymère précis dans un solvant organique non miscible avec l'eau pour préparer une solution, du mélange de cette solution avec de l'eau afin d'obtenir une émulsion organique/aqueuse, puis de la lente volatilisation du solvant organique de la solution, et du chargement de la composition de micelle polymérique avec un médicament peu soluble dans l'eau pouvant être obtenu à l'aide du procédé de fabrication indiqué ci-dessus.

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