Production process of microspheres

Details Production process of microspheres Production process of microspheres

B - Operations, Transporting

01

J

B01J 13/12 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) B01J 13/04 (2006.01)

Patent

CA 2044353

ABSTRACT OF THE DISCLOSURE Upon formation of a drug into microspheres by O/W solvent evaporation, a mixed solvent of at least one water-insoluble solvent and at least one water-miscible solvent is used as a solvent of an oil phase. A fatty acid or a salt thereof may be added to the mixed sol- vent. The oil phase may contain at least one glycerin fatty acid ester and/or at least one propylene glycol fatty acid ester, other than the mixed solvent. The oil phase may also comprise the mixed solvent; a fatty acid or a salt thereof; and at least one glycerin fatty acid ester and/or at least one propylene glycol fatty acid ester. The resulting drug-containing microspheres contain the drug at a high concentration and slowly release from the initial stage after administration.

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