C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/08 (2006.01) A61K 35/36 (2006.01) A61K 38/39 (2006.01) A61L 27/22 (2006.01) A61L 27/60 (2006.01) C07K 14/47 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2143644
The isolated proteins kalinin and k-laminin are disclosed to provide adhesion between epidermal keratinocytes and the un- derlying dermis. Purified kalinin has a molecular weight of approximately 410-495 kDa and exists in a cell-associated form (about 495 kDa) and two medium-associated forms (about 460 and 410 kDa, respectively). The k-laminin adhesion molecule is an isolated heterotrimeric laminin variant that has a molecular weight of about 650 kDa and separates on western blots into first and second fragments that are similar to the B1 and B2 fragments of laminin and a third fragment of 190 kDa that is immunoreactive with a monoclonal antibody BM165, an antibody that is specific to kalinin. Methods of using kalinin or k-laminin for improving adhesion of transplanted keratinocytes to an underlying substrate are disclosed.
Burgeson Robert E.
Keene Douglas R.
Lunstrum Gregory P.
Marinkovich M. Peter
Rousselle Patricia
Oyen Wiggs Green & Mutala Llp
State Of Oregon Acting By And Through The Oregon State Board Of
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