Products and methods for stimulating an immune response

Details Products and methods for stimulating an immune response Products and methods for stimulating an immune response

A - Human Necessities

61

K

A61K 39/385 (2006.01)

Patent

CA 2723226

The present invention provides products which comprise (i) a support and (ii) a BCR-binding antigen attached to the support. The products are capable of BCR-mediated internalization. The products are useful in the induction or augmentation of immune responses, and methods and uses of the products are provided. The present invention also provides methods of delivering an agent preferentially to dendritic cells versus B cells in a population of cells comprising both dendritic and B cells, which methods comprise (i) attaching the agent to a support and (ii) contacting the population of cells with the agent attached to the support, wherein the population of cells comprise B cells and dendritic cells.

L'invention concerne des produits qui comprennent: (i) un support et (ii) un antigène de liaison à BCR attaché au support. Les produits précités sont capables d'une internalisation médiée par BCR. Ces produits sont utiles pour induire ou renforcer les réponses immunitaires. L'invention porte également sur des procédés et des utilisations desdits produits. L'invention se rapporte à des procédés permettant d'administrer un agent de manière préférentielle à des cellules dendritiques plutôt qu'à des cellules B dans une population de cellules comprenant à la fois des cellules dendritiques et des cellules B, lesquels procédés consistent à (i) attacher l'agent à un support et (ii) mettre en contact la population de cellules avec l'agent attaché au support, la population de cellules comprenant des cellules B et des cellules dendritiques.

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