Products comprising a support whereon are fixed nucleic...

Details Products comprising a support whereon are fixed nucleic... Products comprising a support whereon are fixed nucleic...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) B01J 19/00 (2006.01) C07B 61/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2393641

The invention concerns products comprising a support whereon are fixed nucleic acids and their preparation method and use as DNA support. The invention also concerns functionalised supports, oligonucleotides and DNA's modified in position 5' by a group selected in the group consisting of tartaric acid, serine, threonine, their derivatives and the .alpha.-oxoaldehyde group, and the methods for preparing them. The invention further concerns a method for fixing a nucleic acid on a support.

La présente invention se rapporte à des produits comprenant un support sur lequel sont fixés des acides nucléiques, à leur procédé de préparation et à leur utilisation comme puce à ADN. La présente invention se rapporte également à des supports fonctionnalisés, à des oligonucléotides et à des ADN modifiés en position 5' par un groupement sélectionné dans le groupe constitué par l'acide tartrique, la sérine, la thréonine, leurs dérivés et le groupement .alpha.-oxoaldéhyde, ainsi qu'à leurs procédés de préparation. La présente invention se rapporte, en outre, à un procédé de fixation d'un acide nucléique sur un support.

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