Products for altering il-33 activity and methods therefor

Details Products for altering il-33 activity and methods therefor Products for altering il-33 activity and methods therefor

C - Chemistry, Metallurgy

07

K

C07K 14/54 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2685124

Products for altering IL-33 activity including antibodies that specifically bind to an epitope with the polypeptide sequence of IL-33 such as antibodies that specifically bind to a protease cleavage region of IL-33 comprising the amino acid sequence of SEQ ID No. 17, or SEQ ID NO. 16, or SEQ ID NO. 10; isolated IL-33 polypeptide(s); and compositions comprising a soluble IL-33 receptor linked to an enzyme capable of cleaving IL-33 or an antibody that binds to IL-33 linked to an enzyme capable of cleaving IL-33. The invention also relates to methods of altering IL-33 activity using the products described herein.

L'invention porte sur des produits pour modifier l'activité d'IL-33 comprenant des anticorps qui se lient de façon spécifique à un épitope avec la séquence polypeptidique d'IL-33, tels que des anticorps qui se lient de façon spécifique à une région de clivage de protéase d'IL-33, comprenant la séquence d'acides aminés de SEQ ID No. 17, ou SEQ ID NO. 16, ou SEQ ID NO. 10; sur le ou les polypeptides IL-33 isolés; et sur des compositions comprenant un récepteur IL-33 soluble lié à une enzyme capable de cliver IL-33 ou un anticorps qui se lie à IL-33 lié à une enzyme capable de cliver IL-33. L'invention porte également sur des procédés de modification de l'activité. L'invention porte également sur des procédés de modification de l'activité d'IL-33 à l'aide de produits décrits présentement.

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