C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/78 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2500669
The present invention provides products and methods for regulating the degradation of collagen, including type II collagen. Also encompassed are variants, inhibitors, and mimetics of type II collagen peptide fragments and inhibitors of the proteases producing these peptide fragments that are capable of modifying the degradation of collagen whereby the pathological effects of increased collagen destruction are reduced. In addition, the present invention provides methods for treating disease states wherein the disease state results directly or indirectly from the degradation of one or more collagen species. Furthermore, the present invention encompasses the screening of these peptide fragments for diagnostic purposes.
L'invention concerne des produits et des procédés de régulation de la dégradation du collagène, y compris du collagène de type II. Elle concerne aussi des variants, des inhibiteurs, et des mimétiques de fragments peptidiques de collagène de type II et des inhibiteurs de protéases produisant ces fragments peptidiques capables de modifier la dégradation du collagène, permettant de réduire les effets pathologiques de destruction accélérée du collagène. Elle concerne, en outre, des méthodes de traitement de troubles dans lesquels l'état maladif résulte directement ou indirectement de la dégradation d'une ou de plusieurs espèces de collagène. Elle concerne enfin le criblage de ces fragments peptidiques dans un but de diagnostic.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Shriners Hospital For Children
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