Products of condensations of hydroxycoumarin derivatives...

C - Chemistry – Metallurgy – 07 – D

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C07D 311/48 (2006.01) A61K 31/37 (2006.01) A61P 31/18 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2462414

The present invention relates to a novel class of compounds obtained in reactions of condensation of hydroxycoumarin derivatives with aromatic and aliphatic dialdehydes, to their preparation and antiviral action thereof. According to the present ivnention novel derivatives of mono, di and trihydroxycoumarin condensed with aromatic and aliphatic dialdehydes are prepared starting from hydroxycoumarins of general formula (VI) in reactions of condensation with aliphatic and aromatic dialdehydes of the general formula (VII): OHC-R8-CHO wherein R8 = ortho-phenyl or (CH2)n and n = 0 - 3. Novel hydroxy coumarines derivatives of the present invention exhibit antiviral action against HIV.

La présente invention concerne une nouvelle classe de composés issus de réactions de condensation de dérivés d'hydroxycoumarine avec des dialdéhydes aromatiques et aliphatiques, la préparation de ces derniers ainsi que leur action antivirale. Selon la présente invention, on prépare à partir d'hydroxycoumarine représentées par la formule VI, de nouveaux dérivés de monohydroxycoumarine, dihydroxycoumarine et trihydroxycoumarine condensés avec des dialdéhydes aromatiques et aliphatiques, dans des réactions de condensation avec des dialdéhydes aliphatiques et aromatiques représentés par la formule VII, dans laquelle R¿8? = ortho-phényle ou (CH¿2?)¿n?, n étant compris entre 0 et 3. Les nouveaux dérivés d'hydroxycoumarine selon l'invention présentent une action antivirale contre le VIH. Formules VI et VII

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