A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) C12N 5/078 (2010.01) A61P 39/00 (2006.01) C07K 14/42 (2006.01) C12N 15/29 (2006.01) C12N 5/071 (2010.01) A61K 51/00 (2006.01)
Patent
CA 2395625
Disclosed is the FRIL family of progenitor cell preservation factors and nucleic acids encoding the same. FRIL family members preserve progenitor cells both in vivo and ex vivo. FRIL family members find use as therapeutics for alleviating and/or reducing the hematopoietic progenitor cell-depleting activity of many cancer therapeutics. FRIL family members are also useful for isolating rare, primitive progenitor cells.
La présente invention concerne la famille FRIL des facteurs de conservation de cellules souches et les acides nucléiques les codant. Les membres de la famille FRIL sont capables de conserver les cellules souches aussi bien in vivo qu'ex vivo. Ces membres de la famille FRIL conviennent comme agents thérapeutiques capables d'atténuer et/ou de réduire l'activité d'épuisement des cellules souches hématopoïétiques de nombreux agents anticancéreux. Les membres de la famille FRIL conviennent également pour l'isolement de cellules souches primitives rares.
Chrispeels Maarten J.
Colucci M. Gabriella
Moore Jeffrey G.
Imclone Systems Incorporated
Smart & Biggar
The Regents Of The University Of California
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