Progenitor cells and uses thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/10 (2006.01) A61K 35/36 (2006.01) A61P 25/28 (2006.01) C12Q 1/00 (2006.01) G01N 33/68 (2006.01) C12N 15/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2656548

Methods for preparing progenitor cells are described where epithelial cells are induced to undergo epithelial-mes-enchymal transition as a result of exposure to an inducing agent or introduction of a gene therein that induces epithelial-mesenchymal transition. Progenitor cells resulting therefrom have use in cell-based therapies, among other utilities.

L'invention concerne des méthodes permettant de préparer des cellules progénitrices dans lesquelles des cellules épithéliales sont amenées à subir une transition épithéliale-mésenchymale comme résultat de l'exposition à un agent d'induction ou de l'introduction dans lesdites cellules d'un gène qui induit une transition épithéliale-mésenchymale. Les cellules progénitrices résultantes sont entre autre utilisées dans des thérapies cellulaires.

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