Progenitor endothelial cell capturing with a drug eluting...

Details Progenitor endothelial cell capturing with a drug eluting... Progenitor endothelial cell capturing with a drug eluting...

A - Human Necessities

61

L

A61L 27/54 (2006.01) A61F 2/82 (2006.01) A61M 31/00 (2006.01)

Patent

CA 2555364

A medical device for implantation into vessels or luminal structures within the body is provided. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled- release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

L'invention concerne un dispositif médical destiné à être implanté dans des vaisseaux ou des structures luminales à l'intérieur du corps. Ce dispositif médical, par exemple un stent ou un greffon synthétique, est revêtu d'une composition pharmaceutique comprenant une matrice à libération contrôlée et une ou plusieurs substances pharmaceutiques pour permettre l'administration directe de médicaments à des tissus environnants. Le revêtement sur le dispositif médical comprend en outre un ligand, par exemple un anticorps ou une petite molécule servant à capturer des cellules endothéliales progénitrices dans la surface du dispositif en contact avec le sang, afin de permettre de reconstituer l'endothélium sur le site de la lésion. En particulier, les stents revêtus de médicaments sont destinés à être utilisés, par exemple dans des procédures d'angioplastie par ballonnet afin de prévenir ou d'inhiber une resténose.

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