Progenitor endothelial cell capturing with a drug eluting...

A - Human Necessities – 61 – L

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A61L 31/16 (2006.01) A61F 2/00 (2006.01) A61K 35/44 (2006.01) A61M 31/00 (2006.01)

Patent

CA 2626805

A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

La présente invention concerne un dispositif médical pour une implantation dans des vaisseaux ou des structures luminales à l'intérieur du corps, qui stimule le remodelage de vaisseaux sanguins positif. Le dispositif médical, tel qu~un stent et une greffe synthétique, est revêtu d~une composition pharmaceutique consistant en une matrice à libération contrôlée et une ou plusieurs substances pharmaceutiques pour une libération directe de médicaments vers les tissus environnants. Le revêtement du dispositif médical comprend en outre un ligand tel qu~un peptide, un anticorps ou une petite molécule destinée à capturer des cellules endothéliales progénitrices dans la surface en contact avec le sang du dispositif pour restaurer un endothélium au niveau du site de lésion. En particulier, les stents revêtus de médicaments sont destinés à une utilisation, par exemple, dans des actes d~angioplastie à ballonnet pour prévenir ou inhiber la resténose.

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