Progestin therapy with controlled bleeding

Details Progestin therapy with controlled bleeding Progestin therapy with controlled bleeding

A - Human Necessities

61

K

A61K 31/57 (2006.01) A61K 9/10 (2006.01) A61K 9/70 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2307615

The present invention teaches that dialy, cyclical vaginal delivery of progestin may be used to provide regular, predictable withdrawal bleeding during hormone replacement therapy. The present invention also teaches that constant administration of progestin in a water-insoluble, water-swellable cross-linked polycarboxylic acid polymer may be used to maintain amenorrhea. Either regimen is accompanied by a significant decrease in adverse side effects.

Selon la présente invention, on peut procéder à une administration journalière, cyclique de progestine par voie vaginale pour obtenir une hémorragie de privation régulière prévisible dans le cadre d'une hormonothérapie substitutive. Selon la présente invention, on peut également effectuer une administration constante de progestine contenue dans un polymère d'acide polycarboxylique non hydrosoluble, gonflant dans l'eau et réticulé, pour maintenir l'aménorrhée. Ces deux types de traitement sont accompagnés d'une réduction importante d'effets secondaires indésirables.

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