C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/06 (2006.01) A61K 35/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2522727
The present invention is based on the unexpected discovery that the loss of cells in inflamed tissue during chronic inflammation leads to the influx and long-term re-population of the tissue with bone marrow derived stem cells, and that it is these stem cells that are the primary source of metaplasia and cancer. Accordingly, the invention relates to various methods, reagents and kits for prognosing, diagnosing, staging, monitoring, preventing and treating cancers, particularly cancers associated with chronic inflammation.
La présente invention repose sur la découverte inattendue que la perte de cellules dans du tissu enflammé lors d'une inflammation chronique entraîne l'influx et le repopulation à long terme du tissu avec de la moelle épineuse dérivée de cellules souches, et que ce sont ces cellules souches qui constituent la source primaire de la métaplasie et du cancer. Par conséquent, l'invention a trait à divers procédés, réactifs et trousses pour le pronostic, le diagnostic, la stadification, le suivi, la prévention et le traitement de cancers, notamment des cancers associés à l'inflammation chronique.
Houghton Jeanmarie
Wang Timothy C.
Borden Ladner Gervais Llp
University Of Massachusetts
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