Prognostic methods for breast cancer

Details Prognostic methods for breast cancer Prognostic methods for breast cancer

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61B 10/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/574 (2006.01) G01N 33/78 (2006.01)

Patent

CA 2441763

Methods of determining the likelihood of the re-occurrence of tumors and of determining the aggressiveness of post-surgical treatment are provided which rely on analysis of a loss of heterogeneity at the particular chromosomal locus 3p24.3. Loss of expression or hypermethylation of the thyroid hormone receptor .beta.1 gene is also predictive of an increased re-occurrence of tumors.

L'invention concerne des méthodes de détermination de la probabilité de récidive de tumeurs et de détermination de l'agressivité d'un traitement post-chirurgical. Lesdites méthodes reposent sur l'analyse d'une perte d'hétérogénéité au niveau du locus chromosomique 3p24.3. La perte d'expression ou l'hyperméthylation du gène du récepteur .beta.1 des hormones thyroïdiennes sont également prédictives d'une récidive accrue de tumeurs.

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