Prognostic testing of organs intended for transplantation

A - Human Necessities – 61 – B

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A61B 17/43 (2006.01) A61B 17/435 (2006.01) G01N 33/70 (2006.01)

Patent

CA 2390599

The present invention discloses a method of prospectively determining whether an organwill function once it is transplanted. A transplantable organ is perfused in an ex vivo warmperfusion system capable of supporting near normal levels of metabolism by the organ. One ormore parameters related to organ function are measured and evaluated during perfusion. Measurements of perfused organ function are compared to values indicative of normal organfunction to obtain a prediction of whether the organ being perfused will function once it has beentransplanted. A method for calculating a viability index based on the parameters evaluated is also disclosed.

L'invention concerne une méthode pour déterminer à l'avance si un organe est susceptible de fonctionner après transplantation. Un organe devant être transplanté est mis sous perfusion dans un système de perfusion chaude ex vivo capable d'assurer le métabolisme presque normal d'un organe. Durant cette perfusion, on mesure et on évalue un ou plusieurs paramètres concernant le fonctionnement de l'organe. Les mesures du fonctionnement de l'organe soumis à perfusion sont comparées à des valeurs indicatives du fonctionnement d'un organe normal, afin d'obtenir une estimation quant à l'aptitude de l'organe soumis à perfusion à fonctionner après transplantation. L'invention concerne également une méthode de calcul d'un indice de viabilité sur la base des paramètres évalués.

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