Programmed cell death and caspase-12

Details Programmed cell death and caspase-12 Programmed cell death and caspase-12

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C07H 21/04 (2006.01) C12N 1/20 (2006.01) C12N 9/50 (2006.01) C12N 9/64 (2006.01) C12N 15/00 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2327516

This invention relates to nucleic acids encoding caspase-12, proteins encoded by casp-12 nucleic acids, vectors, and hosts transformed with vectors. Caspase- 12 is a member of the caspase family, which also includes mammalian interleukin-1.beta.-converting enzyme (ICE). Caspases are thought to carry out the execution phase of apoptosis in a cascade of proteolytic events. The invention also relates to the use of caspase-12 to induce programmed cell death.

L'invention concerne des acides nucléiques codant une caspase-12, des protéines codées par des acides nucléiques de casp-12, des vecteurs et des hôtes transformés par des vecteurs. Caspase-12 est un membre de la famille des caspases comprenant également l'enzyme de conversion d'interleukin-1.beta. mammalienne. On pense que les caspases réalisent la phase d'exécution de l'apoptose dans une cascade d'événements protéolytiques. L'invention concerne également l'utilisation de caspase-12 pour induire une mort cellulaire programmée.

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