Programmed immune responses using a vaccination node

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) A61K 9/08 (2006.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01) A61K 47/30 (2006.01) A61P 31/00 (2006.01) A61P 37/02 (2006.01)

Patent

CA 2531032

The present invention provides compositions and methods for modulating immune responses to antigens. One aspect of the present invention relates to a particle-based antigen delivery system (vaccination node) that comprises a hydrogel particle capable of both antigen presentation and DC activation. The VN may further comprise a chemoattractant-loaded microsphere capable of attracting DCs to the site of administration. Another aspect of the present invention relates to the use of the VN to modulate antigen presenting cells activation for the prevention and/treatment of various diseases, such as infectious diseases, cancers and autoimmune diseases.

La présente invention a trait à des compositions et de procédés permettant la modulation des réponses immunitaires aux antigènes. Dans un mode de réalisation, la présente invention a trait à un système de délivrance d'antigènes à base de particules (noeud de vaccination) comprenant une particule d'hydrogel capable à la fois de présentation de l'antigène et d'activation de cellules dendritiques. Le noeud de vaccination peut comprendre en outre une microsphère chargée d'un facteur chimiotactique capable d'attirer les cellules dendritiques vers le site d'administration. Dans un autre mode de réalisation, l'invention a trait à l'utilisation du noeud de vaccination pour la modulation de l'activation des cellules présentatrices de l'antigène pour la prévention et/ou le traitement de diverses maladies, telles que des maladies infectieuses, des cancers et des maladies auto-immunes.

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