G - Physics – 01 – N
Patent
G - Physics
01
N
358/9
G01N 33/48 (2006.01) G01N 31/12 (2006.01) H01J 49/04 (2006.01)
Patent
CA 1074869
ABSTRACT OF THE DISCLOSURE A method facilitating the rapid and objective classification and/or identification of an unknown biolog- ical specimen is disclosed. A physical sample of the specimen is controllably heated in accordance with a pre- determined nonisothermal time dependent function causing the sample to undergo controlled thermal degradation and give off a characteristic time dependent sequence or evolution pattern of gaseous degradation components (molecular fragments). This sequence of gaseous degrada- tion components is then directly passed into an ionization source and ionized to provide a respectively corresponding time dependent sequence of characteristic ions. These ions are then analyzed in a mass spectrometer and measured data is recorded representing the respective quantities of ions having particular masses being produced as a function of time or temperature. This recorded data for an unknown biological specimen is then correlated with analogous time or temperature dependent data earlier recorded for known biological specimen thereby facilitating the classification and/or identification of the unknown biological specimen. The method may be used to facilitate the classification and identification of many different types of biological speci- men such as, for example, biological organisms (e.g., bacteria, yeast, molds, fungi, viruses and unicellular animals) and/or biological tissues (e.g., lymphocytes, leukocytes, phagocytes, erythrocytes and platelets). - 1 -
277579
Risby Terence H.
Yergey Alfred L. (iii)
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