C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C12N 5/10 (2006.01) C12N 15/867 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2727681
The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to chimeric animals comprising reprogrammed somatic cells of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
Cette invention concerne un procédé permettant de reprogrammer une ou plusieurs cellules somatiques, par exemple, des cellules partiellement différenciées et/ou entièrement/définitivement différenciées, en les ramenant à un état moins différencié, par exemple, un état pluripotent ou multipotent. Dans d'autres modes de réalisation, l'invention concerne également des cellules somatiques reprogrammées produites par des procédés selon l'invention, des animaux chimériques comprenant des cellules somatiques reprogrammées selon l'invention, les utilisations desdites cellules, et des procédés pour identifier des agents utiles pour reprogrammer des cellules somatiques.
Carey Bryce Woodbury
Jaenisch Rudolf
Smart & Biggar
Whitehead Institute For Biomedical Research
LandOfFree
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