Progression inhibitor for disease attributed to abnormal...

A - Human Necessities – 61 – K

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A61K 31/7034 (2006.01) A61P 1/16 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2572793

A pharmaceutical composition that is effective as a progression inhibitor for diseases attributed to the abnormal accumulation of liver fat. In particular, there is provided a pharmaceutical composition characterized by containing a sodium/glucose cotransporter 2 inhibitor as an active ingredient. This pharmaceutical composition because of capability of inhibiting any abnormal accumulation of fat in the liver is highly suitable for use as a progression inhibitor for not only general fatty liver but also non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), hyperalimentation-induced fatty liver, diabetic fatty liver, alcohol-induced fatty liver or toxic fatty liver.

L~invention concerne une composition pharmaceutique qui est efficace en tant qu~inhibiteur de la progression de maladies attribuées à une accumulation anormale de corps gras dans le foie. En particulier, il est fourni une composition pharmaceutique caractérisée du fait qu~elle contient un inhibiteur du cotransporteur 2 de sodium/glucose en tant que principe actif. Cette composition pharmaceutique, du fait de sa capacité à inhiber toute accumulation anormale de corps gras dans le foie, convient très bien pour une utilisation en tant qu'inhibiteur de la progression non seulement d'une stéatose générale mais également d~une stéatose non alcoolique (NAFL), d~une stéato-hépatite non alcoolique (NASH), d~une stéatose induite par une suralimentation, d~une stéatose alcoolique ou d~une stéatose toxique.

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