Prohormone convertase transformed cells

Details Prohormone convertase transformed cells Prohormone convertase transformed cells

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C07K 14/62 (2006.01) C07K 14/64 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 15/12 (2006.01) C12N 15/16 (2006.01) C12N 15/19 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2123430

Described is the production of mammalian cells expressing prohormone convertase which facilitates the processing of pro- hormone precursors to active hormones. Also described are variant prohormone convertases, and prohormones. The transformed cells of the present invention may be used in the synthesis of properly processed polypeptide hormones, and in cell culture to re- duce dependence upon added hormones and required serum polypeptide factors.

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