Prohormone convertase transformed cells and polypeptide...

Details Prohormone convertase transformed cells and polypeptide... Prohormone convertase transformed cells and polypeptide...

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 31/7088 (2006.01) A61K 35/34 (2006.01) A61K 48/00 (2006.01) A61P 5/50 (2006.01) C07K 14/62 (2006.01) C12N 9/64 (2006.01) C12N 15/17 (2006.01)

Patent

CA 2155434

Described is the production of mammalian cells expressing prohormone convertase which facilitates the processing of prohormone precursors to active hormones. Also described are variant prohormone convertases, and prohormones. The transformed cells of the present invention may be used in the synthesis of properly processed polypeptide hormones, and in cell culture to reduce dependence upon added hormones and required serum polypeptide factors.

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