Projection against mycobacterial infections

Details Projection against mycobacterial infections Projection against mycobacterial infections

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/7088 (2006.01) A61K 39/04 (2006.01) A61K 39/385 (2006.01) A61K 39/40 (2006.01) A61P 31/04 (2006.01) C07K 14/35 (2006.01) C07K 16/12 (2006.01) C12N 1/20 (2006.01) C12N 15/11 (2006.01) C12N 15/31 (2006.01) C12N 15/74 (2006.01) C12N 15/85 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2433665

The present invention relates to a method of identifying mycobacterial genes which wre induced or up-regulated during M. tuberculosis virulence, and to isolated peptide products of said genes. Also provided, are inhibitors of said genes, and antibodies which bind to said peptide products. Further embodiments include DNA and RNA vectors encoding said products, attenuated mycobacteria in which the activity of at least one of said genes or peptide products has been modified, vaccines against mycobacterial infections, and methods of detecting a mycobacterial infection.

La présente invention se rapporte à une méthode d'identification de gènes mycobactériens qui sont induits ou régulés positivement au cours d'une période de virulence de <i>M. tuberculosis</i>, ainsi qu'à des produits peptidiques isolés desdits gènes. L'invention se rapporte également à des inhibiteurs de ces gènes et à des anticorps qui se lient auxdits produits peptidiques. D'autres réalisations de l'invention concerne des vecteurs d'ADN et d'ARN codant lesdits produits, des mycobactéries atténuées dans lesquelles l'activité d'au moins un desdits gènes ou produits peptidiques a été modifié, des vaccins contre les infections mycobactériennes ainsi que des méthodes de détection d'une infection mycobactérienne.

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