C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/37 (2006.01) C12N 1/21 (2006.01) C12N 9/50 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2360022
The invention relates to a prokaryotic cell system for monitoring protease activity. The invention also includes assays for identifying protease inhibitors and protease modulators, determining the amino acid squence of a protease cleavage site for a known protease, identifying and cloning a protease whose cleavage site is known, and rapidly identifying a form of a protease exhibiting increased activity relative to a control protease.
La présente invention concerne un système cellulaire procaryote permettant de surveiller une activité protéase. Cette invention concerne aussi des analyses permettant d'identifier des inhibiteurs de protéases et des modulateurs de protéases, lesquelles analyses consistent à déterminer la séquence d'acides aminés d'un site de restriction protéasique d'une protéase connue, identifier et cloner une protéase dont le site de restriction est connu, et identifier rapidement la forme d'une protéase présentant une augmentation d'activité par rapport à une protéase témoin.
Lach David
Patel Pramathesh
Wittekind Michael
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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