Prokaryotically produced antibodies and uses thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/13 (2006.01) A61K 47/48 (2006.01) C07K 16/00 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01) C07K 16/42 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01)

Patent

CA 2430182

The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full-length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.

La présente invention concerne des procédés et des compositions permettant l'expression et la production améliorées d'anticorps de recombinaison dans des systèmes d'expression procaryotes. Plus particulièrement, la présente invention concerne la production et l'expression procaryotes d'anticorps non glycosylés pleine longueur. Les produits des anticorps décrits dans cette invention peuvent être utilisés dans divers aspects de la recherche biologique, du diagnostic et du traitement médical.

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