A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2746339
This application relates to the use of agents such as expression vectors and nucleic acids encoding integrins .alpha.6 or .alpha.6B as well as antibodies specific for those integrins which are capable of modulating the ratio between the B and A isoforms of the .alpha.6 integrin in the treatment of diseases associated with an altered proliferation rate, such as cancer. The application also relates to the use of the ratio between the B and A isoforms of the .alpha.6 integrin in the diagnosis of diseases associated with an altered proliferation rate.
La présente invention concerne l'utilisation d'agents tels que des vecteurs d'expression et des acides nucléiques codant pour des intégrines a6A ou a6B, qui sont capables de moduler le rapport entre les isoformes B et A de l'intégrine a6 dans le traitement de maladies associées à un taux de prolifération altérée, tel que le cancer. L'invention porte en outre sur l'utilisation du rapport entre les isoformes B et A de l'intégrine a6 dans le diagnostic de maladies associées à un taux de prolifération altérée.
Basora Nuria
Beaulieu Jean-Francois
Groulx Jean-Francois
Herring Elizabeth
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Socpra Sciences Sante Et Humaines S.e.c.
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