Proline derivatives

Details Proline derivatives Proline derivatives

C - Chemistry, Metallurgy

07

K

530/5.08

C07K 5/10 (2006.01) C07K 5/065 (2006.01) C07K 5/068 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) C07K 5/09 (2006.01) C07K 5/107 (2006.01) C07K 5/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1253297

ABSTRACT Proline derivatives of the formulae: (I) Image (II) (III) wherein R1 through R11 have defined values, and acid- and base-addition salts thereof, and equilibrium addition compounds of the aldehyde group thereof; processes for their preparation; pharmaceutical compositions; and intermediates for preparing said proline derivatives. The proline derivatives are human leukocyte elastase inhibitors which are useful, for example, in treating pulmonary emphysema.

452712

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