C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/325, 260/306
C07D 207/08 (2006.01) C07D 207/16 (2006.01) C07D 403/06 (2006.01)
Patent
CA 2010035
New proline derivatives of the general formula: (see fig. I) wherein R stands for a lower alkyl group and X for a N-terminal protective group conventional in amino acid chemistry or an acyl group derived from an amino acid with a protective group at the N-terminal. They have inhibitory activity against prolylendopeptidase and are relatively chemically stable as compared with known compounds of this type.
Nouveaux dérivés de la proline de formule générale : (voir fig. I) où R correspond à un groupe alkyle inférieur et X à un groupe protecteur N-terminal traditionnel en chimie des acides aminés ou un groupe acyle dérivé d'un acide aminé portant un groupe protecteur N-terminal. Ces dérivés ont une activité inhibitrice à l'égard de la prolylendopeptidase et sont relativement stables chimiquement comparativement aux composés connus de ce type.
Hamada Yasumasa
Irako Naoko
Kado Kunio
Shiori Takayuki
Kabushiki Kaisha Yakult Honsha
Kirby Eades Gale Baker
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