Proline derivatives and process for producing the same

Details Proline derivatives and process for producing the same Proline derivatives and process for producing the same

C - Chemistry, Metallurgy

07

D

260/306.1, 260/3

C07D 207/16 (2006.01) C07D 209/20 (2006.01) C07D 403/12 (2006.01)

Patent

CA 1235120

Abstract of the Disclosure Proline derivatives of the formula (I): Image (I) wherein R is an acyl group bonded to the .alpha.-amino group of amino acid and is selected from the group consisting of cyclopropanecarbonyl, cyclohexanecarbonyl and adamantanecarbonyl groups; A is glycine, sarcosine or .alpha.-D-amino acid residue and has an .alpha.-carbonyl group that forms a thiol ester bond with a sulfur atom, or a pharmaceutically acceptable salt thereof, and a process for producing the same are disclosed. The proline derivatives are useful for treating hypertension due to angiotension II, and as an agent to treat cardiac insufficience.

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