C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/395 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2418656
The invention aims at providing compounds which exhibit therapeutic effects through the inhibition of DPP-IV and are satisfactory as drugs. The invention has been accomplished by finding that .gamma.-substituted proline derivatives of the general formula (I) exhibit potent DPP-IV inhibitory activities and improving the same in stability. [In the general formula, each symbol is as defined in the description.]
La présente invention concerne des composés qui, faisant preuve d'une action thérapeutique par inhibition des DPP-IV, conviennent particulièrement comme médicaments. Il s'est avéré que les dérivés .gamma.-substitués de proline tels que représentés par la formule générale (I) se comportent comme de puissants inhibiteurs des DPP-IV. L'invention a également impliqué une amélioration de la stabilité de ces dérivés. Les différents symboles de la formule générale (I) sont tels que définis dans la description.
Akahoshi Fumihiko
Hayashi Yoshiharu
Kitajima Hiroshi
Sakashita Hiroshi
Fetherstonhaugh & Co.
Mitsubishi Pharma Corporation
Mitsubishi Tanabe Pharma Corporation
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