Proliposome powders for inhalation stabilised by tocopherol

Details Proliposome powders for inhalation stabilised by tocopherol Proliposome powders for inhalation stabilised by tocopherol

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 9/72 (2006.01) A61K 31/355 (2006.01) A61K 31/573 (2006.01) A61K 31/58 (2006.01) A61K 47/22 (2006.01) A61P 11/08 (2006.01)

Patent

CA 2295028

There is described a proliposome powder, said powder comprising discrete particles each comprising in a single phase (1) a biologically active component, (2) a stabilising proportion of tocopherol, and (3) a lipid or mixture of lipids having a phase transition temperature of below 37 ~C. Also described is a process for the preparation of, and the pharmaceutical use of, the powder.

L'invention concerne une poudre de proliposomes contenant des particules distinctes renfermant chacune, dans une phase unique, (1) un composant biologiquement actif, (2) une proportion de tocophérol stabilisatrice, et (3) un lipide ou un mélange de lipides ayant une température de transition de phase inférieure à 37 ·C. L'invention concerne également un procédé de préparation et l'utilisation de cette poudre.

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