Prolonged anesthesia in joints and body spaces

Details Prolonged anesthesia in joints and body spaces Prolonged anesthesia in joints and body spaces

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 9/16 (2006.01) A61K 31/166 (2006.01) A61K 31/167 (2006.01) A61K 31/245 (2006.01) A61K 31/57 (2006.01) A61K 47/02 (2006.01) A61K 47/36 (2006.01) B01J 13/02 (2006.01) B32B 5/16 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2271750

Sustained release local anesthetic formulations are administered intra articularly and/or into body spaces/cavities. The formulation is preferably a plurality of injectable microparticles including a local anesthetic and an effective amount of a biocompatible, biodegradable, sustained release material prolonging the release of the local anesthetic and optionally a pharmaceutically acceptable, i.e., non-toxic, augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable without the augmenting agent.

La présente invention concerne des formulations d'anesthésies locales à libération prolongée administrées par voie intra-articulaire et/ou dans les espaces ou les cavités corporelles. De préférence, la formulation est sous forme d'une pluralité de microparticules injectables comprenant un anesthésiant local, une quantité efficace d'un produit biocompatible, biodégradable et à libération prolongée, prolongeant la libération de l'anesthésiant local, et éventuellement, un agent d'augmentation pharmaceutiquement acceptable, c.-à-d.,non toxique, prolongeant efficacement la durée de l'anesthésie locale au-delà de la durée obtenue sans agent d'augmentation.

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