Prolonged ion resonance collision induced dissociation in a...

H - Electricity – 01 – J

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H01J 49/42 (2006.01)

Patent

CA 2760278

A technique is disclosed for conducting collision induced dissociation (CID) in a quadrupole ion trap (QIT) having higher order field components. In order to compensate for the shift in the frequency of motion with amplitude of the excited ions arising from the influence of higher-order field components, the amplitude of the RF voltages applied to the QIT is monotonically varied during the excitation period to prolong the condition of resonance, resulting in higher average kinetic energies of the excited ions. Thus, higher fragmentation efficiencies may be obtained, or a targeted level of fragmentation may be achieved in less time relative to conventional CID.

La présente invention concerne une technique permettant de réaliser une dissociation induite par collision (CID) dans un piège ionique quadripolaire (QIT) comportant des composantes de champ d'ordre supérieur. Dans le but de compenser le décalage de la fréquence de mouvement avec l'amplitude des ions excités provenant de l'influence des composantes de champ d'ordre supérieur, l'amplitude des tensions RF appliquées au QIT est modifiée de façon monotone au cours de la période d'excitation pour prolonger la condition de résonance, ce qui entraîne une augmentation des énergies cinétiques moyennes des ions excités. Ainsi, de plus grandes efficacités de fragmentation peuvent être obtenues, ou bien un niveau ciblé de fragmentation peut être obtenu en moins de temps qu'avec une CID classique.

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