Prolonged preservation of blood platelets

Details Prolonged preservation of blood platelets Prolonged preservation of blood platelets

C - Chemistry, Metallurgy

12

N

C12N 5/08 (2006.01) A01N 1/02 (2006.01) A61K 35/14 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2246345

This invention provides a method for prolonging the preservation of human blood platelets at reduced temperatures. The method uses an inhibitor system that enables blood platelets to retain their functional integrity during storage. In addition, the inhibitor system prevents the generation of cytokines in the platelet preparation during storage at both 22 ~C and 4 ~C. This is accomplished by interrupting normal platelet function during storage, so as to help keep platelets from activating and losing their shape. Before using the platelets in a transfusion, they are returned to their normal functional level by washing the inhibitor system away from the platelets.

L'invention concerne un procédé destiné à prolonger la conservation des plaquettes sanguines humaines à basse température. Le procédé utilise un système d'inhibiteurs permettant aux plaquettes sanguines de conserver leur intégrité fonctionnelle pendant leur stockage. De plus, le système d'inhibiteurs empêche la génération de cytokines dans la préparation plaquettaire pendant un stockage à la fois à 22 ·C et à 4 ·C. Pour ce faire, on interrompt la fonction plaquettaire normale pendant le stockage, de manière à aider à empêcher les plaquettes de s'activer et de perdre leur forme. Avant l'utilisation des plaquettes dans une transfusion, elles sont ramenées à leur niveau fonctionnel normal par élimination du système d'inhibiteurs desdites plaquettes par lavage.

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