Prolonged preservation of blood platelets

Details Prolonged preservation of blood platelets Prolonged preservation of blood platelets

A - Human Necessities

01

N

A01N 1/00 (2006.01) A01N 1/02 (2006.01) A61K 35/14 (2006.01)

Patent

CA 2201108

This invention provides a method for prolonging the preservation of human blood platelets at reduced temperatures. The method uses an inhibitor system that enables blood platelets to maintain their discoid shape and retain their functional integrity during storage. This is accomplished by interrupting normal platelet function during storage, so as to help keep platelets from activating and losing their shape. Before using the platelets in a transfusion, they are returned to their normal functional level by washing the inhibitor system away from the platelets.

La présente invention concerne un procédé de prolongation de la conservation des plaquettes sanguines humaines à température réduite. Le procédé met en oeuvre un système inhibiteur permettant aux plaquettes sanguines de conserver leur forme discoïde et de conserver leur intégrité fonctionnelle pendant le stockage. Le procédé consiste à interrompre les fonctions normales des plaquettes pendant le stockage pour empêcher que les plaquettes ne s'activent et perdent leur forme. Avant d'utiliser les plaquettes en transfusion, un lavage élimine le système inhibiteur des plaquettes, ce qui leur fait reprendre leur niveau fonctionnel normal.

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