Prolonged release microcapsules

Details Prolonged release microcapsules Prolonged release microcapsules

A - Human Necessities

61

K

A61K 38/09 (2006.01) A61K 9/50 (2006.01) B01J 13/02 (2006.01)

Patent

CA 2316159

Disclosed is a use of a microcapsule of LH-RH or analogue thereof for suppressing initial burst of LH-RH without adding a drug-retaining substance. The microcapsule is produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing about 20 to 70% (w/w) of LH-RH or analogue thereof and an oil layer containing a polymer having a lactic acid/glycolic acid ratio of 80/20 to 100/0, and then subjecting the water-in-oil emulsion to microencapsulation.

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